Pharmacology Solutions
Featuring In vitro assays and in vivo ADME-PK studies
In Vitro
In Vitro Assays Available:
- Absorption
- Caco-2 cell permeability
- Intestinal perfusion study
- Efflux transporters (P-gp, BCRP)
- Distribution
- Protein binding (plasma, tissue homogenate)
- Blood to plasma concentration ratio
- Metabolism
- Metabolic stability (hepatocytes, microsomes, S9, plasma, etc.)
- Metabolic reaction phenotyping
- Metabolite identification
- Enzyme inhibition
- Enzyme induction
- Excretion/Transportation
- Transporter (SLC, ABC) substrate
- Transporter (SLC, ABC) inhibition
In Vivo
In Vivo Studies Available
- PK and BA studies
- Single-dose
- Multiple-dose
- Dose proportionality
- Tissue distribution studies
- Metabolite identification studies
- Plasma
- Urine
- Feces
- Bile
- Excretion studies
- Urine
- Feces
- Bile
- Radiolabeled mass balance studies
- Carbon-14
- Tritium
- Iodine-125
- Iodine-131
